CASE FOR DIAGNOSIS Mucosal Papules in a 9-Year-Old Girl
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چکیده
A punch biopsy of one of the lingual papules revealed wellcircumscribed nodular lesions in the dermis, consisting of hyperplastic nerve fibers that were positive for neurofilament and S100 staining (Fig. 2). Based on these histological finding magnetic resonance imaging of the adrenal glands was performed, and levels of urine catecholamines and blood calcitonin were determined. All test results were normal. However, thyroid ultrasound revealed 3 vascularized, hypodense, bilateral nodules, strongly suggesting malignancy. A genetic study revealed a mutation in the RET proto-oncogene (p.Met918Thr).
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